Safety Comparison Table# Research Evidence Comparison# MariTide Research# MariTide's key evidence comes from a phase 2 trial published in the New England Journal of Medicine (2025): Design: 592 participants across two cohorts -- obesity without T2D, and obesity with T2D -- over 52 weeks Obesity cohort: Mean weight loss ranged from -12.3% to -16.2% with MariTide vs -2.5% with placebo (up to 20% in some analyses) Obesity + T2D cohort: Mean weight loss ranged from -8.4% to -12.3% with MariTide vs -1.7% with placebo
SUSTAIN-6 (cardiovascular outcomes in T2D, Marso et al., NEJM 2016) reported a 26% reduction in MACE versus placebo over 104 weeks, the original cardiovascular signal that established the GLP-1 class's broader metabolic-protection profile beyond glycaemic control
Wegovys official safety information lists nausea, diarrhea, vomiting, constipation, stomach pain, bloating, belching, gas, and heartburn among common possible side effects, which is why this post stays practical and careful
This peptide may help support metabolic balance, body composition goals, and overall wellness